Drug Information

Drug General Information
Drug ID
D0W9PG
Former ID
DIB016590
Drug Name
Pyrazinoylguanidine
Synonyms
PZG
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Discontinued in Phase 2 [545139]
Company
Sparta Pharmaceuticals Inc
Canonical SMILES
N(C(=O)c1nccnc1)C(=N)N
CAS Number
CAS 60398-24-5
Target and Pathway
Target(s) Sodium channel Target Info Modulator [528291]
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and Ankyrins
References
Ref 545139Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002279)
Ref 528291Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem. 2006 Jul 13;49(14):4098-115.

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