Drug Information

Drug General Information
Drug ID
D0W4QB
Former ID
DIB016903
Drug Name
EPI-12323 combination therapy
Synonyms
EPI-12323 combination therapy (asthma/ COPD); EPI-12323 combination therapy (asthma/ COPD), EpiGenesis; EPI-12323 + beta agonist (asthma/COPD), EpiGenesis
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Phase 1 [547408]
Company
EpiGenesis Pharmaceuticals Inc
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [543746]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 547408Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015988)
Ref 543746(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 29).

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