Drug Information

Drug General Information
Drug ID
D0VZ8S
Former ID
DIB007124
Drug Name
KA-398
Synonyms
Scopinast; Scopinast, Wilmar Schwabe
Indication Asthma [ICD10:J45] Terminated [546278]
Company
Dr Willmar Schwabe GmbH & Co
Canonical SMILES
c12oc(=O)ccc2cc(c(c1)OCCCN1CCC(C(c2ccc(cc2)F)(c2ccc(cc2<br />)F)O)CC1)OC
CAS Number
CAS 145574-90-9
Target and Pathway
Target(s) Histamine H1 receptor Target Info Modulator [543664]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 546278Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007218)
Ref 543664(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 262).

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