Drug Information

Drug General Information
Drug ID
D0VZ5X
Former ID
DIB016394
Drug Name
BI-44370 TA
Synonyms
BI-44370; Calcitonin gene-related peptide antagonist (migraine), Boehringer Ingelheim
Indication Migraine [ICD9: 346; ICD10:G43] Phase 2 [522435]
Company
Boehringer Ingelheim Corp
Canonical SMILES
C1CN(C(=O)Nc2c1cccc2)C1CCN(CC1)C(=O)C[C@@H](C(=O)N1CCC(<br />CC1)N1CCOCC1)Cc1cc(c(c(c1)C)O)C
Target and Pathway
Target(s) Calcitoningene-related peptide type 1 receptor Target Info Antagonist [531309]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome G alpha (s) signalling events
Calcitonin-like ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 522435ClinicalTrials.gov (NCT00751803) BI 44370 TA in Acute Migraine Attack. U.S. National Institutes of Health.
Ref 531309BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia. 2011 Apr;31(5):573-84.

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