Drug Information

Drug General Information
Drug ID
D0V9HH
Former ID
DIB013145
Drug Name
Taprizosin
Synonyms
UK-338003
Drug Type
Small molecular drug
Indication Prostate hyperplasia [ICD10:N40] Discontinued in Phase 2 [547527]
Company
Pfizer Inc
Formula
C25H26N6O4S
Canonical SMILES
n1c(nc2c(c(c(c(c2)OC)OC)c2ncccc2)c1N)N1Cc2c(c(NS(=O)(=O<br />)C)ccc2)CC1
CAS Number
CAS 210538-44-6
PubChem Compound ID
6433102
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Antagonist [528839]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 547527Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017098)
Ref 528839Impact of physicochemical and structural properties on the pharmacokinetics of a series of alpha1L-adrenoceptor antagonists. Drug Metab Dispos. 2007 Aug;35(8):1435-45. Epub 2007 May 14.

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