Drug Information

Drug General Information
Drug ID
D0V7KU
Former ID
DNC013376
Drug Name
2-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528998]
Formula
C13H7Cl2N3
Canonical SMILES
C1=CC2=CN=C(N=C2N=C1)C3=CC(=CC(=C3)Cl)Cl
InChI
1S/C13H7Cl2N3/c14-10-4-9(5-11(15)6-10)13-17-7-8-2-1-3-16-12(8)18-13/h1-7H
InChIKey
UDWGFUUPZLVQFW-UHFFFAOYSA-N
PubChem Compound ID
44435041
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528998]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528998Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. Epub 2007 Aug 6.Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.
Ref 528998Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. Epub 2007 Aug 6.Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.

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