Drug Information

Drug General Information
Drug ID
D0V7GC
Former ID
DIB008730
Drug Name
Rolafagrel
Synonyms
FCE-22178
Drug Type
Small molecular drug
Indication Nephritis [ICD10:N00-N19, N25-N29] Discontinued in Phase 2 [544896]
Company
Pharmacia & Upjohn AB
Formula
C14H12N2O2
Canonical SMILES
C1(=Cc2cc(C(=O)O)ccc2CC1)n1cncc1
CAS Number
CAS 89781-55-5
PubChem Compound ID
56009
Target and Pathway
Target(s) Thromboxane-A synthase Target Info Inhibitor [529293]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
References
Ref 544896Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001438)
Ref 529293Inhibition by FCE 22178 of platelet and glomerular thromboxane synthase in animal and human kidney disease. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:707-10.

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