Drug Information

Drug General Information
Drug ID
D0V5ZP
Former ID
DIB018906
Drug Name
ATC0065
Synonyms
ATC-0065; ATC 0065
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538800]
Formula
C25H29BrF3N5O
InChI
InChI=1S/C25H29BrF3N5O/c1-34(2)23-20-5-3-4-6-21(20)32-24(33-23)31-19-11-9-18(10-12-19)30-14-13-16-7-8-17(26)15-22(16)35-25(27,28)29/h3-8,15,18-19,30H,9-14H2,1-2H3,(H,31,32,33)/t18-,19+
InChIKey
FWKVXHBRMCTKHZ-KDURUIRLSA-N
PubChem Compound ID
11238212
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [527402]
Melanin-concentrating hormone receptor 2 Target Info Antagonist [527402]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, Other
References
Ref 538800(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1304).
Ref 527402Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther. 2005 May;313(2):831-9. Epub 2005 Jan 26.

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