TTD | Drug: D0V5OS

Drug General Information
Drug ID	D0V5OS
Former ID	DIB019993
Drug Name	H87/07
Synonyms	H 87-07
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540823]
Formula	C15H25NO4
InChI	InChI=1S/C15H25NO4/c1-12(2)16-10-13(17)11-20-15-6-4-14(5-7-15)19-9-8-18-3/h4-7,12-13,16-17H,8-11H2,1-3H3
InChIKey	FGAPARDHTDKREN-UHFFFAOYSA-N
PubChem Compound ID	193122
PubChem Substance ID	14973066, 22395567, 24524123, 33513958, 52489334, 85209772, 103101018, 103383999, 113455100, 117535259, 125706201, 135169751, 135650344, 162833177, 163355725
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Antagonist	[525440]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
Reactome	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540823	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 542).
Ref 525440	LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5.

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Drug Information