Drug Information

Drug General Information
Drug ID
D0V4RK
Former ID
DIB016630
Drug Name
DPP-IV inhibitors
Synonyms
DPP-IV inhibitors (type 2 diabetes); DPP-IV inhibitors (type 2 diabetes), Toray
Indication Non-insulin dependent diabetes [ICD10:E11.9] Investigative [552120]
Company
Toray Industries Inc
Canonical SMILES
C1CC(CCO1)(c1nc2ccc(cc2s1)OCCOC)NC(=O)C[C@@H](Cc1cc(c(c<br />c1F)F)F)N
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Inhibitor [543447]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 552120Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7036-40
Ref 543447(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612).

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