Drug Information

Drug General Information
Drug ID
D0V4NY
Former ID
DIB012136
Drug Name
Cathepsin C inhibitors
Synonyms
Cathepsin C inhibitors (inflammation); Cathepsin C inhibitors (inflammation), Merck & Co
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [528870]
Company
Merck & Co Inc
Canonical SMILES
c1([C@H]2C[C@]2(NC(=O)[C@H](Cc2sccc2)N)C#N)ccccc1
Target and Pathway
Target(s) Dipeptidyl-peptidase I Target Info Inhibitor [543599]
KEGG Pathway Lysosome
NetPath Pathway IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
MHC class II antigen presentation
Cargo concentration in the ER
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 528870J Biol Chem. 2007 Jul 20;282(29):20836-46. Epub 2007 May 29.Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.
Ref 543599(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2344).

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