Drug Information

Drug General Information
Drug ID
D0V4GI
Former ID
DNC011501
Drug Name
CGS-9896
Drug Type
Small molecular drug
Indication Discovery agent Terminated [544687]
Formula
C16H10ClN3O
Canonical SMILES
C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
InChI
1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H
InChIKey
QCBUAKLOWCOUCR-UHFFFAOYSA-N
PubChem Compound ID
108030
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528080]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 544687Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000585)
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

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