Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V3NT
|
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| Former ID |
DNC005392
|
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| Drug Name |
TOLOXATONE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [528273] | ||
| Formula |
C11H13NO3
|
||||
| Canonical SMILES |
CC1=CC(=CC=C1)N2CC(OC2=O)CO
|
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| InChI |
1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3
|
||||
| InChIKey |
MXUNKHLAEDCYJL-UHFFFAOYSA-N
|
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| CAS Number |
CAS 29218-27-7
|
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| PubChem Compound ID | |||||
| SuperDrug ATC ID |
N06AG03
|
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| Target and Pathway | |||||
| Target(s) | Amine oxidase [flavin-containing] A | Target Info | Inhibitor | [528273] | |
| Amine oxidase [flavin-containing] B | Target Info | Inhibitor | [526287] | ||
| BioCyc Pathway | Superpathway of tryptophan utilization | ||||
| Dopamine degradation | |||||
| Putrescine degradation III | |||||
| Noradrenaline and adrenaline degradation | |||||
| Serotonin degradation | |||||
| Superpathway of melatonin degradation | |||||
| Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization | |||||
| Tryptophan degradation via tryptamine | |||||
| KEGG Pathway | Glycine, serine and threonine metabolism | ||||
| Arginine and proline metabolism | |||||
| Histidine metabolism | |||||
| Tyrosine metabolism | |||||
| Phenylalanine metabolism | |||||
| Tryptophan metabolism | |||||
| Drug metabolism - cytochrome P450 | |||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Dopaminergic synapse | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholismhsa00260:Glycine, serine and threonine metabolism | |||||
| Alcoholism | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | ||||
| References | |||||
| Ref 526287 | J Med Chem. 2002 Mar 14;45(6):1180-3.3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. | ||||
| Ref 528273 | J Nat Prod. 2006 Jun;69(6):945-9.Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: extraction, biological analysis, and computational study. | ||||
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