Drug Information

Drug General Information
Drug ID
D0V0YP
Former ID
DNC006466
Drug Name
3-(thiophen-3-yl)-1H-indol-6-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528040]
Formula
C12H10N2S
Canonical SMILES
C1=CC2=C(C=C1N)NC=C2C3=CSC=C3
InChI
1S/C12H10N2S/c13-9-1-2-10-11(6-14-12(10)5-9)8-3-4-15-7-8/h1-7,14H,13H2
InChIKey
QEKXSCXVUJXAFF-UHFFFAOYSA-N
PubChem Compound ID
44410875
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase 2 Target Info Inhibitor [528040]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides de novo biosynthesis
Superpathway of purine nucleotide salvage
Purine nucleotides de novo biosynthesis
Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway Purine metabolism
Drug metabolism - other enzymes
Metabolic pathways
PANTHER Pathway De novo purine biosynthesis
Reactome Purine ribonucleoside monophosphate biosynthesis
References
Ref 528040Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors.
Ref 528040Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors.

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