Drug Information

Drug General Information
Drug ID
D0V0YM
Former ID
DIB015871
Drug Name
MK-5596
Synonyms
CB1 inverse agonists (obesity), Merck
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Investigative [543877]
Company
Merck Research Laboratories
Formula
C27H23Cl3N4O2
Canonical SMILES
c1c([nH]nc1C(=O)N[C@H]1c2cc(c3ccc(cc3)Cl)c(nc2OC(C)(C)C<br />1)c1ccc(cc1Cl)Cl)C
PubChem Compound ID
24871527
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Agonist [543877]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).
Ref 543877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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