Drug Information

Drug General Information
Drug ID
D0V0OM
Former ID
DIB018192
Drug Name
[18F]FP-TZTP
Synonyms
[18F]FP-TZTP (PET ligand)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540233]
Formula
C11H16FN3S2
InChI
InChI=1S/C11H16FN3S2/c1-15-6-2-4-9(8-15)10-11(14-17-13-10)16-7-3-5-12/h4H,2-3,5-8H2,1H3/i12-1
InChIKey
NQKPPQNBFQLLIZ-DWSYCVKZSA-N
PubChem Compound ID
449812
PubChem Substance ID
190, 1340, 10300414, 15491462, 36891309, 80453525, 104641632, 178100309
Target and Pathway
Target(s) Muscarinic receptor Target Info Agonist [526587]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540233(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3266).
Ref 526587Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice. Neuropharmacology. 2003 Apr;44(5):653-61.

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