Drug Information

Drug General Information
Drug ID
D0U7HD
Former ID
DIB005933
Drug Name
SQ-33961
Indication Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Terminated [544974]
Company
Squibb Corp
Canonical SMILES
c1(nc(co1)C(=O)NCCCCC1CCCCC1)[C@H]1[C@H]([C@H]2O[C@@H]1<br />CC2)Cc1c(CCC(=O)O)cccc1
CAS Number
CAS 139067-88-2
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Modulator [551648]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 544974Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001755)
Ref 551648Conformationally-restricted analogs of TXA2 antagonist SQ 33,961: Receptor binding conformation of the carboxyl sidechain. Bioorganic & Medicinal Chemistry Letters Volume 1, Issue 9, 1991, Pages 465-470.

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