Drug Information

Drug General Information
Drug ID
D0U7BH
Former ID
DIB018070
Drug Name
(+)-norfenfluramine
Synonyms
(S)-norfenfluramine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539369]
Formula
C10H12F3N
InChI
InChI=1S/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3/t7-/m0/s1
InChIKey
MLBHFBKZUPLWBD-ZETCQYMHSA-N
PubChem Compound ID
9815618
PubChem Substance ID
14773143, 15171751, 24120289, 44851589, 47880078, 48105163, 48179702, 48253938, 48253939, 50076580, 80908839, 90340920, 103556029, 128611224, 135650733, 135696251, 136351630, 139972395, 162808682, 177749796, 230574337
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Agonist [525929]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 539369(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 216).
Ref 525929Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41.

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