Drug Information

Drug General Information
Drug ID
D0U4WP
Former ID
DIB021248
Drug Name
YM44781
Synonyms
YM-44781; YM 44781
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539345]
Formula
C31H32Cl2FN3O2
InChI
InChI=1S/C31H32Cl2FN3O2/c1-36(30(39)21-6-9-25(34)10-7-21)20-24(22-8-11-27(32)28(33)18-22)12-15-37-16-13-31(14-17-37)26-5-3-2-4-23(26)19-29(38)35-31/h2-11,18,24H,12-17,19-20H2,1H3,(H,35,38)
InChIKey
MIXOPBNZLJBQJH-UHFFFAOYSA-N
PubChem Compound ID
10483085
PubChem Substance ID
15506995, 40610676, 80564218, 135651347, 244621108
Target and Pathway
Target(s) NK-2 receptor Target Info Antagonist [526310]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539345(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2121).
Ref 526310Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002 May;65(2):96-102.

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