Drug Information

Drug General Information
Drug ID
D0U4QZ
Former ID
DIB012712
Drug Name
EU-517
Synonyms
Mcl-1 inhibitors (cancer), Eutropics; BH3 mimetics/Mcl-1 inhibitors (cancer), Eutropics
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543733]
Company
Harvard Medical School
Target and Pathway
Target(s) Induced myeloid leukemia cell differentiation protein Mcl-1 Target Info Inhibitor [543733]
KEGG Pathway PI3K-Akt signaling pathway
MicroRNAs in cancer
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
CCKR signaling map ST
Pathway Interaction Database E2F transcription factor network
Direct p53 effectors
IL6-mediated signaling events
HIF-1-alpha transcription factor network
WikiPathways Apoptosis
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
Apoptosis Modulation and Signaling
References
Ref 543733(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2847).
Ref 543733(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2847).

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