Drug Information

Drug General Information
Drug ID
D0U3JD
Former ID
DNC007178
Drug Name
1-methyl-1H-indole-2,3-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528749]
Formula
C9H7NO2
Canonical SMILES
CN1C2=CC=CC=C2C(=O)C1=O
InChI
1S/C9H7NO2/c1-10-7-5-3-2-4-6(7)8(11)9(10)12/h2-5H,1H3
InChIKey
VCYBVWFTGAZHGH-UHFFFAOYSA-N
PubChem Compound ID
16358
Target and Pathway
Target(s) Liver carboxylesterase Target Info Inhibitor [528749]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

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