Drug Information

Drug General Information
Drug ID
D0TM0Z
Former ID
DNC008601
Drug Name
1H-indole-4,7-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529405]
Formula
C8H5NO2
Canonical SMILES
C1=CC(=O)C2=C(C1=O)C=CN2
InChI
1S/C8H5NO2/c10-6-1-2-7(11)8-5(6)3-4-9-8/h1-4,9H
InChIKey
QMRIWYCCTCNABA-UHFFFAOYSA-N
PubChem Compound ID
152300
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [529405]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 529405J Med Chem. 2008 May 8;51(9):2634-7. Epub 2008 Apr 8.Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A.
Ref 529405J Med Chem. 2008 May 8;51(9):2634-7. Epub 2008 Apr 8.Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A.

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