Drug Information

Drug General Information
Drug ID
D0TH6L
Former ID
DIB020508
Drug Name
N-desalkylquetiapine
Synonyms
norquetiapine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527620]
Formula
C17H17N3S
InChI
InChI=1S/C17H17N3S/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15/h1-8,18H,9-12H2
InChIKey
JLOAJISUHPIQOX-UHFFFAOYSA-N
PubChem Compound ID
11369918
PubChem Substance ID
16462970, 23525356, 42449147, 49833587, 74458620, 91612199, 117670514, 121278643, 125796408, 126731279, 128292487, 134358675, 135595726, 135707888, 136895425, 137187968, 137354742, 143497646, 151993572, 152236950, 160841887, 162058038, 162120005, 163406888, 163589539, 170558937, 187032767, 187051846, 223578304, 223654964, 223964253, 226399546, 241108396, 251855594, 252236817, 252304551, 252552995
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [529198]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 527620Antipsychotic and antidepressive effects of second generation antipsychotics: two different pharmacological mechanisms. Eur Arch Psychiatry Clin Neurosci. 2005 Jun;255(3):190-201.
Ref 529198N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology. 2008 Sep;33(10):2303-12. Epub 2007 Dec 5.

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