Drug Information

Drug General Information
Drug ID
D0TG9Q
Former ID
DIB010467
Drug Name
MK-0812
Synonyms
C-6448; MK-812; CCR2 antagonist (rheumatoid arthritis/multiple sclerosis), Merck
Drug Type
Small molecular drug
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Phase 2 [521746]
Company
Merck & Co Inc
Formula
C24H34F3N3O3
Canonical SMILES
C1OCCC([C@@H]1OC)N[C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CCc2c(<br />C1)cc(cn2)C(F)(F)F
CAS Number
CAS 1011472-76-6
PubChem Compound ID
71296092
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [530515]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 521746ClinicalTrials.gov (NCT00239655) A Study to Assess the Effects of MK0812 on Disease Activity in Patients With Relapsing-Remitting Multiple Sclerosis as Measured by Magnetic Resonance Imaging (MRI). U.S. National Institutes of Health.
Ref 530515Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.

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