Drug Information

Drug General Information
Drug ID
D0TE6A
Former ID
DNC004291
Drug Name
1,5-Dihydro-imidazo[2,1-b]quinazolin-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533367]
Formula
C10H9N3O
Canonical SMILES
C1C2=CC=CC=C2NC3=NC(=O)CN31
InChI
1S/C10H9N3O/c14-9-6-13-5-7-3-1-2-4-8(7)11-10(13)12-9/h1-4H,5-6H2,(H,11,12,14)
InChIKey
YLVVAWCDANPADI-UHFFFAOYSA-N
PubChem Compound ID
10130278
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [533367]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 533367J Med Chem. 1988 Nov;31(11):2136-45.Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
Ref 533367J Med Chem. 1988 Nov;31(11):2136-45.Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.

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