Drug Information

Drug General Information
Drug ID
D0T7AR
Former ID
DIB018518
Drug Name
2-(3-chlorophenyl)histamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538706]
Formula
C11H12ClN3
InChI
InChI=1S/C11H12ClN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15)
InChIKey
DHGUFKPZDMQBED-UHFFFAOYSA-N
PubChem Compound ID
14827778
PubChem Substance ID
47510100, 48105228, 56469829, 103193253, 127734685, 135649685, 136352272, 216142900, 218502627, 229081902
Target and Pathway
Target(s) Histamine H1 receptor Target Info Agonist [526569]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538706(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1195).
Ref 526569Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.

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