Drug Information

Drug General Information
Drug ID
D0T6VU
Former ID
DIB006204
Drug Name
ED-110
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Terminated [545230]
Company
MSD Japan
Formula
C26H21N3O9
Canonical SMILES
n1([C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)c2c3c(c4<br />c(c2c2c1c(O)ccc2)c(=O)[nH]c4=O)c1c([nH]3)c(O)ccc1
CAS Number
CAS 139112-73-5
PubChem Compound ID
54692974
Target and Pathway
Target(s) Toposisomerase-1 Target Info Modulator [525422]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 545230Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002530)
Ref 525422Indolocarbazole poisons of human topoisomerase I: regioisomeric analogues of ED-110. Bioorg Med Chem Lett. 1999 Jan 18;9(2):145-50.

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