Drug Information

Drug General Information
Drug ID
D0T3DO
Former ID
DIB003449
Drug Name
IRX-5183
Synonyms
AGN-195183; NRX-195183; NRX-5183; VTP-195183; VTP-5183; IRX-5183 (oral, autoimmune disease), Io Therapeutics; RARa (oral, cancer/autoimmune disease), Io Therapeutics; RARa agonist (topical, skin/eye diseases), Io Therapeutics; Retinoic acid receptor alpha agonist (oral, cancer/autoimmune disease), Io Therapeutics; Retinoic acid receptor alpha agonist (topical, skin/eye diseases), Io Therapeutics; IRX-5183 (oral, cancer/autoimmune disease), Io Therapeutics; IRX-5183 (topical, skin/eye diseases), Io Therapeutics
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [547464]
Company
Vitae Pharmaceuticals
Canonical SMILES
c1(C(=O)Nc2cc(c(c(c2)F)C(=O)O)F)c(c(c2c(c1)C(CCC2(C)C)(<br />C)C)Cl)O
CAS Number
CAS 367273-07-2
Target and Pathway
Target(s) Retinoic acid receptor alpha Target Info Agonist [526923], [529087]
KEGG Pathway Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear Receptors
References
Ref 547464Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016603)
Ref 526923Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat. J Mol Med (Berl). 2004 Feb;82(2):116-25. Epub 2004 Jan 8.
Ref 529087Tamibarotene. Drugs Today (Barc). 2007 Aug;43(8):563-8.

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