Drug Information

Drug General Information
Drug ID
D0T1SP
Former ID
DIB019178
Drug Name
compound 1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531863], [541405]
Formula
C18H17N3
InChI
InChI=1S/C18H17N3/c1-2-6-15(7-3-1)21-13-14(12-20-21)16-10-11-19-18-9-5-4-8-17(16)18/h1-11,14,20H,12-13H2
InChIKey
KQNXOSZPTJGHDO-UHFFFAOYSA-N
PubChem Compound ID
73755198
PubChem Substance ID
178102857
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Modulator (allosteric modulator) [531863]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transduction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 5318634-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators. Bioorg Med Chem Lett. 2012 May 1;22(9):3235-9.
Ref 541405(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6236).
Ref 5318634-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators. Bioorg Med Chem Lett. 2012 May 1;22(9):3235-9.

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