Drug Information

Drug General Information
Drug ID
D0SK3A
Former ID
DIB018973
Drug Name
BIIL 260
Synonyms
BIIL-260; BIIL260
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541344]
Formula
C30H30N2O3
InChI
InChI=1S/C30H30N2O3/c1-30(2,24-8-12-26(33)13-9-24)25-10-16-28(17-11-25)35-20-22-5-3-4-21(18-22)19-34-27-14-6-23(7-15-27)29(31)32/h3-18,33H,19-20H2,1-2H3,(H3,31,32)
InChIKey
MBLJFKQACMILLC-UHFFFAOYSA-N
PubChem Compound ID
9956189
PubChem Substance ID
14931832, 24225420, 46052796, 47880128, 48253995, 79000185, 128571595, 140136970, 163642014, 178102775, 198986383, 230874508
Target and Pathway
Target(s) Leukotriene B4 receptor 2 Target Info Antagonist [528578]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 541344(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6154).
Ref 528578Clinical trial of a leucotriene B4 receptor antagonist, BIIL 284, in patients with rheumatoid arthritis. Ann Rheum Dis. 2007 May;66(5):628-32. Epub 2006 Dec 14.

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