Drug Information

Drug General Information
Drug ID
D0S6VX
Former ID
DIB007375
Drug Name
CGP-40215A
Drug Type
Small molecular drug
Indication Pneumocystis carinii infection [ICD10:B59] Terminated [534214]
Company
Novartis AG
Formula
C17H22Cl3N9
Canonical SMILES
C(=N)(N/N=C/c1cc(C(=N)N)ccc1)N/N=C/c1cc(C(=N)N)ccc1.Cl.<br />Cl.Cl
CAS Number
CAS 126534-93-8
PubChem Compound ID
9576797
Target and Pathway
Target(s) S-adenosylmethioninedecarboxylase proenzyme Target Info Modulator [534214], [535793]
BioCyc Pathway Methionine salvage cycle III
Spermine biosynthesis
Spermidine biosynthesis
KEGG Pathway Cysteine and methionine metabolism
Arginine and proline metabolism
Metabolic pathways
NetPath Pathway EGFR1 Signaling Pathway
PathWhiz Pathway Spermidine and Spermine Biosynthesis
Methionine Metabolism
WikiPathways Metabolism of amino acids and derivatives
References
Ref 534214Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
Ref 534214Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
Ref 535793S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.

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