Drug Information

Drug General Information
Drug ID
D0S6GY
Former ID
DIB001862
Drug Name
SER-101
Synonyms
RO-1160367
Indication Congestive heart failure [ICD9: 428; ICD10:I50] Phase 1 [549179]
Company
Roche Holding AG
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [550359]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 549179Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033318)
Ref 550359Phase I clinical trail of SER101 (RO1160367) for treating heart failure leukemia. Roche.

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