Drug Information

Drug General Information
Drug ID
D0S4JY
Former ID
DIB013453
Drug Name
Ro-24-4736
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Discontinued in Phase 2 [544808]
Company
Roche Holding AG
Formula
C31H20ClN5OS
Canonical SMILES
c12c(C(=NCc3n1c(nn3)C)c1c(Cl)cccc1)cc(s2)C#CCn1c(=O)c2c<br />(c3c1cccc3)cccc2
CAS Number
CAS 125030-71-9
PubChem Compound ID
60775
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [528091]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544808Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001180)
Ref 528091Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736. J Pharmacol Exp Ther. 1991 Oct;259(1):78-85.

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