Drug Information

Drug General Information
Drug ID
D0S3YN
Former ID
DIB012322
Drug Name
FE-202158
Synonyms
V1a agonist (septic shock), Ferring; Vasopressin 1a agonist (septic shock), Ferring
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Phase 2 [523936]
Company
Ferring Pharmaceuticals Inc
Formula
C46H73N13O11S2
Canonical SMILES
N(CC(=O)N)C(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1NC(<br />=O)[C@@H](NC(=O)[C@H](CCCC(=O)N)NC(=O)[C@@H](NC(=O)[C@@<br />H](NC(=O)[C@@H](N)CSSC1)Cc1ccccc1)[C@@H](C)CC)CC(=O)N)C<br />CCNC(C)C
PubChem Compound ID
53330936
Target and Pathway
Target(s) Vasopressin V1a receptor Target Info Agonist [532722]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 523936ClinicalTrials.gov (NCT01612676) Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock. U.S. National Institutes of Health.
Ref 532722The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-33.

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