Drug Information

Drug General Information
Drug ID
D0S2WC
Former ID
DIB011529
Drug Name
Nerisopam
Synonyms
EGIS-6775
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 1 [544884]
Company
EGIS Gyogyszergyar RT
Formula
C18H19N3O2
Canonical SMILES
N1=C(c2c(cc(c(c2)OC)OC)CC(=N1)C)c1ccc(N)cc1
CAS Number
CAS 102771-12-0
PubChem Compound ID
65875
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [534238]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544884Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001415)
Ref 534238Simultaneous determination of nerisopam, a novel anxiolytic agent showing polymorphic metabolism, and its N-acetyl metabolite from human plasma by a validated high performance liquid chromatographic method. J Chromatogr B Biomed Appl. 1996 Mar 29;678(1):63-72.

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