Drug Information

Drug General Information
Drug ID
D0S2MO
Former ID
DIB019877
Drug Name
FR194921
Synonyms
FR-194921; FR 194921
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540524]
Formula
C23H23N5O
InChI
InChI=1S/C23H23N5O/c1-26-15-12-18(13-16-26)28-21(29)11-10-19(24-28)22-20-9-5-6-14-27(20)25-23(22)17-7-3-2-4-8-17/h2-11,14,18H,12-13,15-16H2,1H3
InChIKey
YHDRUTMZCJZJAL-UHFFFAOYSA-N
PubChem Compound ID
9821511
PubChem Substance ID
14780426, 24124924, 44857471, 74921790, 85223944, 129795259, 135650289, 172649676, 198986645, 233102539
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Antagonist [527203]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540524(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 387).
Ref 527203Pharmacological characterization of FR194921, a new potent, selective, and orally active antagonist for central adenosine A1 receptors. J Pharmacol Sci. 2004 Sep;96(1):42-52. Epub 2004 Sep 4.

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