Drug Information

Drug General Information
Drug ID
D0S1PM
Former ID
DIB001463
Drug Name
RBx-2258
Synonyms
Pamirosin; Parvosin; SPM-969
Indication Prostate hyperplasia [ICD10:N40] Discontinued in Phase 2 [547000]
Company
Ranbaxy Laboratories Ltd
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Antagonist [544170]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 547000Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011920)
Ref 544170Drug Metabolism and Pharmacokinetics. Indian J Pharmacol. 2008 October; 40(Suppl 2): S91-S97.

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