Drug Information

Drug General Information
Drug ID
D0RG8O
Former ID
DIB020007
Drug Name
histaprodifen
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540629]
Formula
C20H23N3
InChI
InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)
InChIKey
BPZGZNLONLANFE-UHFFFAOYSA-N
PubChem Compound ID
10447834
PubChem Substance ID
15468972, 40575473, 49846678, 75076548, 92729721, 103172042, 135360069, 178100852, 229074004, 241053625
Target and Pathway
Target(s) Histamine H1 receptor Target Info Agonist [527589]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 540629(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4026).
Ref 527589Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21. Epub 2005 Jun 9.

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