Drug Information

Drug General Information
Drug ID
D0RC0H
Former ID
DIB016806
Drug Name
NPY Y5 antagonists
Synonyms
NPY Y5 antagonists (obesity, depression); NPY Y5 antagonists (obesity, depression), GlaxoSmithKline
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Investigative [552083]
Company
GlaxoSmithKline plc
Canonical SMILES
c1cccc(c1F)n1ccc(NC[C@@H]2CC[C@@]3(OC(=O)N(c4cccnn4)C3)<br />CC2)n1
Target and Pathway
Target(s) Neuropeptide Y receptor 5 Target Info Antagonist [543759]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 552083Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7120-3
Ref 543759(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 308).

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