Drug Information

Drug General Information
Drug ID
D0R8IU
Former ID
DIB009645
Drug Name
AZD-4017
Synonyms
AZD-4017 (oral tablet, ocular hypertension)
Drug Type
Small molecular drug
Indication Ocular hypertension [ICD9: 365.04; ICD10:H40.0] Phase 2 [523126], [542670]
Company
AstraZeneca plc
Formula
C22H33N3O3S
InChI
InChI=1S/C22H33N3O3S/c1-2-13-29-22-18(21(28)23-17-8-4-3-5-9-17)10-11-19(24-22)25-12-6-7-16(15-25)14-20(26)27/h10-11,16-17H,2-9,12-15H2,1H3,(H,23,28)(H,26,27)/t16-/m0/s1
InChIKey
NCDZABJPWMBMIQ-INIZCTEOSA-N
PubChem Compound ID
24946280
PubChem Substance ID
56243998, 57477902, 138066138, 141846540, 144242173, 163323600, 163341240, 163643074, 198939334, 223366028, 228128143, 248612012, 252822492
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [551800]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 523126ClinicalTrials.gov (NCT01173471) A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure. U.S. National Institutes of Health.
Ref 542670(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7695).
Ref 551800New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).

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