Drug Information

Drug General Information
Drug ID
D0R8FM
Former ID
DIB011790
Drug Name
Ebrotidine
Synonyms
Ebrocit; FI-3542
Drug Type
Small molecular drug
Indication Duodenal ulcers [ICD10:K25-K27] Withdrawn from market [544797]
Company
Ferrer Internacional SA
Formula
C14H17BrN6O2S3
Canonical SMILES
S(=O)(=O)(N/C=N/CCSCc1nc(NC(=N)N)sc1)c1ccc(cc1)Br
CAS Number
CAS 100981-43-9
PubChem Compound ID
65869
Target and Pathway
Target(s) Histamine H2 receptor Target Info Modulator [534410]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 544797Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001139)
Ref 534410Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46.

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