Drug Information

Drug General Information
Drug ID
D0R7JA
Former ID
DIB021065
Drug Name
TMP269
Synonyms
TMFO1; compound 1 [PMID: 23524983]; TMP-269; TMP 269
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532282]
Formula
C25H21F3N4O3S
InChI
InChI=1S/C25H21F3N4O3S/c26-25(27,28)22-31-20(32-35-22)17-7-4-8-18(13-17)21(33)29-15-24(9-11-34-12-10-24)23-30-19(14-36-23)16-5-2-1-3-6-16/h1-8,13-14H,9-12,15H2,(H,29,33)
InChIKey
HORXBWNTEDOVKN-UHFFFAOYSA-N
PubChem Compound ID
53344908
PubChem Substance ID
125009808, 161004193, 162010167, 163835733, 187051794, 194167120, 194944377, 198043965, 210275743, 210281405, 223366676, 224658701, 232644533, 249714960, 251962689, 252216479, 252451373, 252473652
Target and Pathway
Target(s) histone deacetylase 5 Target Info Inhibitor [532282]
histone deacetylase 7 Target Info Inhibitor [532282]
histone deacetylase 9 Target Info Inhibitor [532282]
Histone deacetylase 4 Target Info Inhibitor [532282]
KEGG Pathway Alcoholism
Epstein-Barr virus infection
Viral carcinogenesis
MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class III
Signaling events mediated by HDAC Class I
Sumoylation by RanBP2 regulates transcriptional repression
Validated nuclear estrogen receptor alpha network
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
WikiPathways Endochondral Ossification
Cardiac Hypertrophic Response
Neural Crest Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
TarBasePathway
Cell Cycle
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 532282Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25.
Ref 532282Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25.

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