Drug Information

Drug General Information
Drug ID
D0R5QF
Former ID
DIB018868
Drug Name
AR231453
Synonyms
AR-231,453; AR 231453; AR-231453
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540999]
Formula
C21H24FN7O5S
InChI
InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
InChIKey
DGBKNTVAKIFYNU-UHFFFAOYSA-N
PubChem Compound ID
24939268
PubChem Substance ID
53837672, 57474594, 103586906, 104100719, 141161048, 162220258, 163417530, 163850439, 172650366, 172821437, 178102281, 188919960, 198957260, 210275247, 210280887, 223612984, 226486734, 228819405, 246937865, 252160264, 252451612, 252465310
Target and Pathway
Target(s) Glucose-dependent insulinotropic receptor Target Info Agonist [528663]
KEGG Pathway cAMP signaling pathway
Insulin secretion
WikiPathways Incretin Synthesis, Secretion, and Inactivation
References
Ref 540999(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5653).
Ref 528663A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9. Epub 2007 Feb 8.

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