Drug Information

Drug General Information
Drug ID
D0R2TW
Former ID
DIB019988
Drug Name
GW848687X
Synonyms
GW 848687X; GW-848687X
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540317]
Formula
C24H18ClF2NO3
InChI
InChI=1S/C24H18ClF2NO3/c25-15-8-10-23(31-13-14-7-9-16(26)12-20(14)27)19(11-15)17-3-1-4-18(17)21-5-2-6-22(28-21)24(29)30/h2,5-12H,1,3-4,13H2,(H,29,30)
InChIKey
PFODPHDNBFSMOX-UHFFFAOYSA-N
PubChem Compound ID
10238338
PubChem Substance ID
15240257, 22624313, 41011761, 75825549, 99431580, 103532838, 104079035, 125333963, 139717943, 142898790, 178100386, 224308907, 230105176, 244366842, 251963101
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP1 subtype Target Info Antagonist [528512]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Pathways in cancer
PANTHER Pathway PI3 kinase pathway
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540317(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3360).
Ref 528512The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. Epub 2006 Oct 20.

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