Drug Information

Drug General Information
Drug ID
D0R2HJ
Former ID
DNC012305
Drug Name
Isoquinoline-3-carboxylic acid methyl ester
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533363]
Formula
C11H9NO2
Canonical SMILES
COC(=O)C1=CC2=CC=CC=C2C=N1
InChI
1S/C11H9NO2/c1-14-11(13)10-6-8-4-2-3-5-9(8)7-12-10/h2-7H,1H3
InChIKey
ZBCGBIZQNMVMPC-UHFFFAOYSA-N
PubChem Compound ID
725374
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [533363]
Gamma-aminobutyric acid receptor Target Info Inhibitor [533363]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 533363J Med Chem. 1988 Sep;31(9):1854-61.Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.
Ref 533363J Med Chem. 1988 Sep;31(9):1854-61.Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.

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