Drug Information

Drug General Information
Drug ID
D0R2DP
Former ID
DIB021229
Drug Name
XAP044
Synonyms
7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532694]
Formula
C15H9IO4
InChI
InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChIKey
XXZKJJYWINSUMJ-UHFFFAOYSA-N
PubChem Compound ID
5428913
PubChem Substance ID
4268985, 11679814, 25634129, 39427513, 47905708, 53161898, 71999682, 88877215, 113935882, 117615440, 164245385, 166218704, 223332977, 241493833, 252158718, 252166746
Target and Pathway
Target(s) Metabotropic glutamate receptor 7 Target Info Modulator (allosteric modulator) [532694]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 532694Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014 Apr 18;289(16):10975-87.
Ref 532694Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014 Apr 18;289(16):10975-87.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.