Drug Information

Drug General Information
Drug ID
D0R1QJ
Former ID
DIB009809
Drug Name
D-22888
Synonyms
AWD-12-232
Drug Type
Small molecular drug
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Terminated [546267]
Company
ASTA Medica AG
Formula
C16H20N4O2
Canonical SMILES
n12c(c(=O)n(c3c1nc(cc3)OC)CCC)c(nc2CC)C
CAS Number
CAS 182282-60-6
PubChem Compound ID
197714
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [534736]
Type IV phosphodiesterase Target Info Modulator [534736]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Modulator [534736]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 546267Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007179)
Ref 534736Effects of a selective PDE4 inhibitor, D-22888, on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea pigs. Pulm Pharmacol Ther. 1998 Feb;11(1):13-21.

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