Drug Information

Drug General Information
Drug ID
D0R1ER
Former ID
DNC011986
Drug Name
2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529474]
Formula
C16H13N3O
Canonical SMILES
C1=CC=C2C(=C1)C(=CN2)CN3C(=O)C4=CC=CC=C4N3
InChI
1S/C16H13N3O/c20-16-13-6-2-4-8-15(13)18-19(16)10-11-9-17-14-7-3-1-5-12(11)14/h1-9,17-18H,10H2
InChIKey
IAJFPXRONWWXNK-UHFFFAOYSA-N
PubChem Compound ID
44265197
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [529474]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 529474J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.
Ref 529474J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.

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