Drug Information

Drug General Information
Drug ID
D0R0UZ
Former ID
DNC013404
Drug Name
3-fluoro-5-(1,6-naphthyridin-7-yl)benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529101]
Formula
C15H8FN3
Canonical SMILES
C1=CC2=CN=C(C=C2N=C1)C3=CC(=CC(=C3)C#N)F
InChI
1S/C15H8FN3/c16-13-5-10(8-17)4-12(6-13)15-7-14-11(9-19-15)2-1-3-18-14/h1-7,9H
InChIKey
PSQNPPVCWZBHDY-UHFFFAOYSA-N
PubChem Compound ID
44434724
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [529101]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 529101Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.
Ref 529101Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.

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