Drug Information

Drug General Information
Drug ID
D0R0PU
Former ID
DNC013405
Drug Name
7-(3-fluoro-5-methylphenyl)-1,6-naphthyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529101]
Formula
C15H11FN2
Canonical SMILES
CC1=CC(=CC(=C1)C2=NC=C3C=CC=NC3=C2)F
InChI
1S/C15H11FN2/c1-10-5-12(7-13(16)6-10)15-8-14-11(9-18-15)3-2-4-17-14/h2-9H,1H3
InChIKey
ZJIGDEYNCCHRKX-UHFFFAOYSA-N
PubChem Compound ID
44434723
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [529101]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 529101Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.
Ref 529101Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. Epub 2007 Sep 29.Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.

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